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pentobarbital will reduce the extent or result of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.pentobarbital will lessen the level or outcome of siponimod by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of siponimod that has a